Phenotypes: eGFR_creat, eGFR_cys, BUN, eGFR_creat_EA. Please refer to Stanzick et al. 2021 for more details on the analyses. Contact thomas.winkler@ukr.de if you have questions. /p>
File | Add | Download |
---|---|---|
eGFR_creat | -- | .gzip (254 MB) |
eGFR_creat EA | -- | .gzip (277 MB) |
eGFR_cys | -- | .gzip (219 MB) |
BUN | -- | .gzip (261 MB) |
Within each file, the data are presented as follows:
Chr | chromosome |
Pos | position (build 37) |
RSID | rs identifier |
Allele1 | coded (effect) allele |
Allele2 | noncoded allele |
Freq1 | frequency of allele 1 |
Effect | Beta / effect of association of allele 1 |
StdErr | Standard error, 2nd GC corrected |
P-value | P value, two-sided |
Direction | Direction of effect in UKB and CKDGen data |
MarkerName | SNP identifier (format: <CHR>:<POS_b37>:<A1>_<A2>; with alleles in alphabetical order) |
P.value.GC | Genomic control corrected P-Value |
StdErr.GC | Genomic control corrected standard error |
n | Sample size |
mac | Minor allele count |
The datasets are the ones reported in the manuscript: Rapid3 and CKDi25
File | Add | Download |
---|---|---|
CKDi25 overall | N ckdi25: 19,901 cases and 175,244 controls | .gzip (162 MB) |
Rapid3 overall | N rapid3: 34,874 cases and 107,090 controls | .gzip (161 MB) |
Within each file, the data are presented as follows:
Chr | chromosome |
Pos_b37 | position (build 37) |
RSID | rs identifier |
Allele1 | coded (effect) allele |
Allele2 | noncoded allele |
Freq1 | frequency of allele 1 |
OR | odds ratio of association of allele 1 |
StdErr | Standard error, 2nd GC corrected |
P-value | P value, 2nd GC corrected |
N_total_sum | Number of subjects in analysis |
The datasets are the ones reported in the manuscript: urate trans-ethnic ("all"), European-American ancestry (EA); urate and gout
File | Add | Download |
---|---|---|
Gout, trans-ethnic | IQ > 0.6, MAC > 10, n(studies) >= 10, sum(MAC) >= 400 | .gzip (191 MB) |
Urate, trans-ethnic | IQ > 0.6, MAC > 10, n(studies) >= 37, sum(MAC) >= 400 | .gzip (161 MB) |
Urate, European-American ancestry | IQ > 0.6, MAC > 10, n(studies) >= 30, sum(MAC) >= 400 | .gzip (186 M) |
Notes regarding small p-values | Including example R code how to calculate p-values | .txt (499 bytes) |
Within each file, the data are presented as follows:
Chr | chromosome |
Pos_b37 | position (build 37) |
RSID | rs identifier |
Allele1 | coded (effect) allele |
Allele2 | noncoded allele |
Freq1 | frequency of allele 1 |
Effect | beta coefficient for allele 1 |
StdErr | Standard error, no 2nd GC correction |
P-value | P value |
N_total_sum | Number of subjects in analysis |
The datasets are the ones reported in the manuscript: transethnic, EA-specific, and AA-specific UACR, diabetes-specific UACR, transethnic MA
File | Add | Download |
---|---|---|
UACR overall, trans-ethnic | n(studies) >= 27, sumMac >= 400 | .gzip (149 MB) |
UACR Diabetes mellitus, trans-ethnic | n(studies) >= 18, sumMac >= 400 | .gzip (129 MB) |
UACR overall, European-American ancestry | n(studies) >= 18, sumMac >= 400 | .gzip (193 M) |
UACR overall, African-American ancestry | n(studies) >= 1, sumMac >= 400 | .gzip (183 M) |
Microalbuminuria overall, trans-ethnic | n(studies) >= 18, sumMac >= 400 | .gzip (158 M) |
Within each file, the data are presented as follows:
Chr | chromosome |
Pos_b37 | position (build 37) |
RSID | rs identifier |
Allele1 | coded (effect) allele |
Allele2 | noncoded allele |
Freq1 | frequency of allele 1 |
Effect | beta coefficient for allele 1 |
StdErr | Standard error, no 2nd GC correction |
P-value | P value |
N_total_sum | Number of subjects in analysis |
These files contain the summary meta-analysis data from the CKDGen consortium round 4 analyses.
File | Add | Download |
---|---|---|
eGFRcrea overall trans-ethnic | n(studies) >= 61 | .gzip (141 MB) |
eGFRcrea overall European ancestry | n(studies) >= 42 | .gzip (184 MB) |
BUN overall trans-ethnic | n(studies) >= 33 | .gzip (142 M) |
BUN overall European ancestry | n(studies) >= 24 | .gzip (145 M) |
CKD overall trans-ethnic | n(studies) >= 30 | .gzip (181 M) |
CKD overall European ancestry | n(studies) >= 23 | .gzip (171 M) |
Within each file, the data are presented as follows:
Chr | chromosome |
Pos_b37 | position (build 37) |
RSID | rs identifier |
Allele1 | coded (effect) allele |
Allele2 | noncoded allele |
Freq1 | frequency of allele 1 |
Effect | beta coefficient for allele 1 |
StdErr | Standard error, no 2nd GC correction |
P-value | P value |
N_total_sum | Number of subjects in analysis |
These files contain the summary meta-analysis data from the CKDGen consortium for the following 2 traits from the Gorski et al. 2017 publication:
File | Add | Download |
---|---|---|
eGFRcrea overall | Nmax=110,527 | .gzip (123MB) |
eGFRcys overall | Nmax=24,061 | .gzip (99MB) |
Within each file, the data are presented as follows:
rsID | rs-identifier |
allele1 | coded allele |
allele2 | noncoded allele |
freqA1 | frequency of allele1 calculated from the 1000 Genomes Phase I version 3 (all reference panel available at http://csg.sph.umich.edu/abecasis/MaCH/download/1000G.2012-03-14.html) |
beta | effect is given with 4 digits after the dot |
se | 2nd GC corrected standard error is given with 4 digits after the dot |
pval | double GC corrected p-value rounded to 3 significant digits |
N | Number of subjects in analysis |
The preferred citation is as follows:
These files contain the summary meta-analysis data from the CKDGen consortium for the following 10 traits from the Li et al. 2017 publication:
File | Add | Format |
---|---|---|
eGFRcrea overall EA | Nmax=111,666 | .gzip - 2.9MB |
eGFRcrea DM EA | Nmax=14,308 | .gzip - 1.4MB |
eGFRcrea nonDM EA | Nmax=94,677 | .gzip - 2.8MB |
eGFRcys overall EA | Nmax=32,861 | .gzip - 2MB |
UACR EA | Nmax=31,164 | .gzip - 1.9MB |
eGFRcrea overall AA | Nmax=9,067 | .gzip - 1.9MB |
eGFR DM AA | Nmax=2,162 | .gzip - 1.3MB |
eGFRcrea nonDM AA | Nmax=6,597 | .gzip - 1.3MB |
eGFRcys overall AA | Nmax=4,440 | .gzip - 1.5MB |
UACR AA | Nmax=4,387 | .gzip - 1.6MB |
Single file download (all 10 datasets) | .gzip - 19.5MB |
Within each file, the data are presented as follows:
chr | chromosome |
bp_hg19 | base pair position from hg19 |
rsID | rs-identifier |
allele1 | coded allele |
allele2 | noncoded allele |
beta | is the beta-coefficient for allele1 (rounded to 2 significant digits) |
se | is the standard error (rounded to 2 significant digits) |
pval | is the p-value (rounded to 2 significant digits) |
N | is the sample size |
1KG_(EUR/AFR)_MAF | is the frequency of the minor allele from the 1000G analyses in European or African ancestry |
ExAC_(EUR/AFR)_MAF | is the frequency of the minor allele from ExAC in European or African ancestry |
The preferred citation is as follows:
These files contain the summary meta-analysis data from the CKDGen consortium for the following 5 traits from the Pattaro et al. 2016 publication:
File | Add | Download |
---|---|---|
eGFRcrea | Nmax=133,814 | .gzip (~24MB) |
eGFRcrea_DM | Nmax=11,529 (Updated 3/16/2016) | .gzip (~24MB) |
eGFRcrea_nonDM | Nmax=118,460 | .gzip (~24MB) |
eGFRcys | Nmax=33,152 | .gzip (~22MB) |
CKD | Nmax=118,147 | .gzip (~24MB) |
eGFRcrea_AA | Nmax=16,474 | .gzip (~29MB) |
Within each file, the data are presented as follows:
rsID | |
allele1 | is the coded allele |
allele2 | is the noncoded allele |
freqA1 | is the frequency of allele1 from the Hapmap CEU (European ancestry analyses) or HapMap YRI (African ancestry analyses) |
beta | is the beta-coefficient for allele1 (rounded to 2 significant digits) |
se | is the double GC corrected standard error (rounded to 2 significant digits) |
pval | is the double GC corrected p-value (rounded to 2 significant digits) |
N | is the sample size |
The preferred citation is as follows:
These files contain the summary meta-analysis data from the CKDGen consortium for the following 4 traits from the Teumer et al. 2015 publication:
File | Add | Download |
---|---|---|
UACR | Nmax=54,450 | .gzip (24.7MB) |
UACR_DM | Nmax=5,825 | .gzip (23.0MB) |
UACR_nonDM | Nmax=46,061 | .gzip (24.1MB) |
MA | Nmax=54,116 | .gzip (24.2MB) |
Within each file, the data are presented as follows:
rsID | |
allele1 | is the coded allele |
allele2 | is the noncoded allele |
freqA1 | is the frequency of allele1 from the Hapmap CEU (European ancestry analyses) |
beta | is the beta-coefficient for allele1 (rounded to 2 significant digits) |
se | is the double GC corrected standard error (rounded to 2 significant digits) |
pval | is the double GC corrected p-value (rounded to 2 significant digits) |
N | is the sample size |
The preferred citation is as follows:
These files contain the summary meta-analysis data from the CKDGen consortium for the following 7 traits from the Gorski et al. 2015 publication:
File | Add | Download |
---|---|---|
CKDi overall | Nmax=39,248 | .gzip (29.4MB) |
CKDi25 overall | Nmax=37,486 | .gzip (29.7MB) |
eGFRdecline CKD | Nmax=3,338 | .gzip (30.1MB) |
eGFRdecline noCKD | Nmax=39,653 | .gzip (28.6MB) |
eGFRdecline overall | Nmax=43,008 | .gzip (28.6MB) |
Rapid3 noCKD | Nmax=39,213 | .gzip (29.1MB) |
Rapid3 overall | Nmax=42,551 | .gzip (29.1MB) |
Within each file, the data are presented as follows:
rsID | rs-identifier |
allele1 | coded allele |
allele2 | noncoded allele |
freqA1 | is the frequency of allele1 from the HapMap CEU r28 reference (available at ftp://ftp.ncbi.nlm.nih.gov/hapmap/frequencies/2010-08_phaseII+III/) |
beta | effect is given with 4 digits after the dot |
se | 2nd GC corrected standard error is given with 4 digits after the dot |
pval | double GC corrected p-value rounded to 3 significant digits |
N | Number of subjects in analysis |
The preferred citation is as follows:
These files contain the summary meta-analysis data from the CKDGen consortium for the following 5 traits from the Köttgen et al. 2010 and Boger et al. 2011 publications:
File | Add | Download |
---|---|---|
eGFRcrea | n=67,093 | .gzip (18.3MB) |
eGFRcys | n=20,957 | .gzip (18.4MB) |
CKD | n=62,237 | .gzip (18.1MB) |
UACR | n=31,580 | .gzip (18.3MB) |
MA | n=30,482 | .gzip (18.3MB) |
Within each file, the data are presented as follows:
rsID | |
allele1 | is the coded allele |
allele2 | is the noncoded allele |
freqA1 | is the frequency of allele1 from the Hapmap CEU sample |
direction | refers to the direction of effect for allele1. Can be +/-/0 |
pval | is the double GC corrected p-value |
The preferred citation is as follows:
Listing of Mendelian disorders with known renal phenotypes and meta-analysis results of associations between common variants in Mendelian renal dysfunction genes with estimated glomerular filtration rate and chronic kidney disease.
File | Download |
---|---|
eGFRcrea | .xlsx (2.5MB) |
Details regarding the case numbers and samples can be found within these published documents.