CKDGen consortium

These files contain the summary meta-analysis data from the CKDGen consortium for the following 2 traits from the Gorski et al. 2017 publication:

File Add Download
eGFRcrea overall Nmax=110,527 .gzip (123MB)
eGFRcys overall Nmax=24,061 .gzip (99MB)
Data description
  • Analyses are performed among participants of European ancestry
Data format description

Within each file, the data are presented as follows:

Reference

The preferred citation is as follows:

These files contain the summary meta-analysis data from the CKDGen consortium for the following 10 traits from the Li et al. 2017 publication:

File Add Format
eGFRcrea overall EA Nmax=111,666 .gzip - 2.9MB
eGFRcrea DM EA Nmax=14,308 .gzip - 1.4MB
eGFRcrea nonDM EA Nmax=94,677 .gzip - 2.8MB
eGFRcys overall EA Nmax=32,861 .gzip - 2MB
UACR EA Nmax=31,164 .gzip - 1.9MB
eGFRcrea overall AA Nmax=9,067 .gzip - 1.9MB
eGFR DM AA Nmax=2,162 .gzip - 1.3MB
eGFRcrea nonDM AA Nmax=6,597 .gzip - 1.3MB
eGFRcys overall AA Nmax=4,440 .gzip - 1.5MB
UACR AA Nmax=4,387 .gzip - 1.6MB
Single file download (all 10 datasets) .gzip - 19.5MB
Data description
  • EA indicate analyses performed among participants of European ancestry
  • AA indicate analyses performed among participants of African ancestry
  • DM and nonDM indicate results from analyses stratified by diabetes status
  • All other analyses were performed in the overall group
Data format description

Within each file, the data are presented as follows:

Reference

The preferred citation is as follows:

These files contain the summary meta-analysis data from the CKDGen consortium for the following 5 traits from the Pattaro et al. 2016 publication:

File Add Download
eGFRcrea Nmax=133,814 .gzip (~24MB)
eGFRcrea_DM Nmax=11,529 (Updated 3/16/2016) .gzip (~24MB)
eGFRcrea_nonDM Nmax=118,460 .gzip (~24MB)
eGFRcys Nmax=33,152 .gzip (~22MB)
CKD Nmax=118,147 .gzip (~24MB)
eGFRcrea_AA Nmax=16,474 .gzip (~29MB)
Data description
  • Analyses are performed among participants of European ancestry unless otherwise specified
  • DM and nonDM indicate results from analyses stratified by diabetes status
  • All other analyses were performed in the overall group
  • eGFRcrea_AA were performed among African American participants
Data format

Within each file, the data are presented as follows:

Reference

The preferred citation is as follows:

These files contain the summary meta-analysis data from the CKDGen consortium for the following 4 traits from the Teumer et al. 2015 publication:

File Add Download
UACR Nmax=54,450 .gzip (24.7MB)
UACR_DM Nmax=5,825 .gzip (23.0MB)
UACR_nonDM Nmax=46,061 .gzip (24.1MB)
MA Nmax=54,116 .gzip (24.2MB)
Data description
  • Analyses are performed among participants of European ancestry unless otherwise specified
  • DM and nonDM indicate results from analyses stratified by diabetes status
  • All other analyses were performed in the overall group
Data format description

Within each file, the data are presented as follows:

Reference

The preferred citation is as follows:

These files contain the summary meta-analysis data from the CKDGen consortium for the following 7 traits from the Gorski et al. 2015 publication:

File Add Download
CKDi overall Nmax=39,248 .gzip (29.4MB)
CKDi25 overall Nmax=37,486 .gzip (29.7MB)
eGFRdecline CKD Nmax=3,338 .gzip (30.1MB)
eGFRdecline noCKD Nmax=39,653 .gzip (28.6MB)
eGFRdecline overall Nmax=43,008 .gzip (28.6MB)
Rapid3 noCKD Nmax=39,213 .gzip (29.1MB)
Rapid3 overall Nmax=42,551 .gzip (29.1MB)
Data description
  • Analyses are performed among participants of European ancestry
  • CKD and nonCKD indicate results from analyses stratified by CKD status, where CKD is defined as eGFRcrea <60 ml/min per 1.73 m2 at baseline
  • All other analyses were performed in the overall group
Data format description

Within each file, the data are presented as follows:

Reference

The preferred citation is as follows:

These files contain the summary meta-analysis data from the CKDGen consortium for the following 5 traits from the Köttgen et al. 2010 and Boger et al. 2011 publications:

File Add Download
eGFRcrea n=67,093 .gzip (18.3MB)
eGFRcys n=20,957 .gzip (18.4MB)
CKD n=62,237 .gzip (18.1MB)
UACR n=31,580 .gzip (18.3MB)
MA n=30,482 .gzip (18.3MB)
Data description
All files are based on analyses in the overall samples of participants of European ancestry.
Data format description

Within each file, the data are presented as follows:

References

The preferred citation is as follows:

Listing of Mendelian disorders with known renal phenotypes and meta-analysis results of associations between common variants in Mendelian renal dysfunction genes with estimated glomerular filtration rate and chronic kidney disease.

File Download
eGFRcrea .xlsx (2.5MB)
Data description
  • Table 1:List of Mendelian disorders with primary renal developmental or glomerular related dysfunction
  • Table 2: List of Mendelian disorders with primary renal tubular dysfunction
  • Table 3: List of Mendelian disorders with secondary cause for renal injury
  • Table 4: eGFR meta-analysis results for top associated SNP within each Mendelian kidney disease gene
  • Table 5: CKD meta-analysis results for top eGFR associated SNP within each Mendelian kidney disease gene
  • Table 6: Complete eGFR meta-analysis results of all SNPs in the 258 Mendelian kidney disease genes

Reference

Details regarding the case numbers and samples can be found within these published documents.